STrengthening the REporting of Genetic Association Studies (STREGA)—an extension of the STROBE statement
Identifieur interne : 001F63 ( Main/Exploration ); précédent : 001F62; suivant : 001F64STrengthening the REporting of Genetic Association Studies (STREGA)—an extension of the STROBE statement
Auteurs : Julian Little [Canada] ; Julian P. T. Higgins [Royaume-Uni] ; John P. A. Ioannidis [Grèce, États-Unis] ; David Moher [Canada] ; France Gagnon [Canada] ; Erik Von Elm [Suisse, Allemagne] ; Muin J. Khoury [Géorgie (pays)] ; Barbara Cohen [États-Unis] ; George Davey-Smith [Royaume-Uni] ; Jeremy Grimshaw [Canada] ; Paul Scheet [États-Unis] ; Marta Gwinn [Géorgie (pays)] ; Robin E. Williamson [États-Unis] ; Guang Yong Zou [Canada] ; Kim Hutchings [Canada] ; Candice Y. Johnson [Canada] ; Valerie Tait [Canada] ; Miriam Wiens [Canada] ; Jean Golding [Royaume-Uni] ; Cornelia Van Duijn [Pays-Bas] ; John Mclaughlin [Canada] ; Andrew Paterson [Canada] ; George Wells [Canada] ; Isabel Fortier [Canada] ; Matthew Freedman [États-Unis] ; Maja Zecevic [États-Unis] ; Richard King [États-Unis] ; Claire Infante-Rivard [Canada] ; Alex Stewart [Canada] ; Nick Birkett [Canada]Source :
- Genetic Epidemiology [ 0741-0395 ] ; 2009-11.
English descriptors
- KwdEn :
Abstract
Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the STrengthening the Reporting of OBservational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy‐Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis. Genet. Epidemiol. 33:581–598, 2009. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/gepi.20410
Affiliations:
- Allemagne, Canada, Grèce, Géorgie (pays), Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Bade-Wurtemberg, Californie, Canton de Berne, District de Fribourg-en-Brisgau, Massachusetts, Minnesota, Ontario, Québec, Texas, État de New York
- Berne, Fribourg-en-Brisgau, Montréal, Toronto
- Université McGill, Université de Berne, Université de Toronto
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Khoury</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Cohen, Barbara" sort="Cohen, Barbara" uniqKey="Cohen B" first="Barbara" last="Cohen">Barbara Cohen</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Public Library of Science, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Davey Mith, George" sort="Davey Mith, George" uniqKey="Davey Mith G" first="George" last="Davey-Smith">George Davey-Smith</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Grimshaw, Jeremy" sort="Grimshaw, Jeremy" uniqKey="Grimshaw J" first="Jeremy" last="Grimshaw">Jeremy Grimshaw</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Clinical Epidemiology Program, Department of Medicine, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Scheet, Paul" sort="Scheet, Paul" uniqKey="Scheet P" first="Paul" last="Scheet">Paul Scheet</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>MD Anderson Cancer Center, Department of Epidemiology, University of Texas, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Gwinn, Marta" sort="Gwinn, Marta" uniqKey="Gwinn M" first="Marta" last="Gwinn">Marta Gwinn</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Williamson, Robin E" sort="Williamson, Robin E" uniqKey="Williamson R" first="Robin E." last="Williamson">Robin E. Williamson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author><author><name sortKey="Zou, Guang Yong" sort="Zou, Guang Yong" uniqKey="Zou G" first="Guang Yong" last="Zou">Guang Yong Zou</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Robarts Clinical Trials, Robarts Research Institute, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hutchings, Kim" sort="Hutchings, Kim" uniqKey="Hutchings K" first="Kim" last="Hutchings">Kim Hutchings</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Candice Y" sort="Johnson, Candice Y" uniqKey="Johnson C" first="Candice Y." last="Johnson">Candice Y. Johnson</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Tait, Valerie" sort="Tait, Valerie" uniqKey="Tait V" first="Valerie" last="Tait">Valerie Tait</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Wiens, Miriam" sort="Wiens, Miriam" uniqKey="Wiens M" first="Miriam" last="Wiens">Miriam Wiens</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Golding, Jean" sort="Golding, Jean" uniqKey="Golding J" first="Jean" last="Golding">Jean Golding</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bristol</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia" sort="Van Duijn, Cornelia" uniqKey="Van Duijn C" first="Cornelia" last="Van Duijn">Cornelia Van Duijn</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Mclaughlin, John" sort="Mclaughlin, John" uniqKey="Mclaughlin J" first="John" last="Mclaughlin">John Mclaughlin</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Cancer Care Ontario, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Prosserman Centre for Health Research at the Samuel Lunenfeld Research Institute, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Paterson, Andrew" sort="Paterson, Andrew" uniqKey="Paterson A" first="Andrew" last="Paterson">Andrew Paterson</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Hospital for Sick Children (SickKids), Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Wells, George" sort="Wells, George" uniqKey="Wells G" first="George" last="Wells">George Wells</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Fortier, Isabel" sort="Fortier, Isabel" uniqKey="Fortier I" first="Isabel" last="Fortier">Isabel Fortier</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Genome Quebec and P3G Observatory, McGill University and Genome Quebec Innovation Center, Montréal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Freedman, Matthew" sort="Freedman, Matthew" uniqKey="Freedman M" first="Matthew" last="Freedman">Matthew Freedman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana‐Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Zecevic, Maja" sort="Zecevic, Maja" uniqKey="Zecevic M" first="Maja" last="Zecevic">Maja Zecevic</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>New York</wicri:cityArea></affiliation></author><author><name sortKey="King, Richard" sort="King, Richard" uniqKey="King R" first="Richard" last="King">Richard King</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Infante Ivard, Claire" sort="Infante Ivard, Claire" uniqKey="Infante Ivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Epidemiology, Biostatistics and Occupational Health Faculty of Medicine, McGill University, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Stewart, Alex" sort="Stewart, Alex" uniqKey="Stewart A" first="Alex" last="Stewart">Alex Stewart</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>University of Ottawa Heart Institute, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Birkett, Nick" sort="Birkett, Nick" uniqKey="Birkett N" first="Nick" last="Birkett">Nick Birkett</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Genetic Epidemiology</title><title level="j" type="sub">The Official Publication of the International Genetic Epidemiology Society</title><title level="j" type="abbrev">Genet. Epidemiol.</title><idno type="ISSN">0741-0395</idno><idno type="eISSN">1098-2272</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-11">2009-11</date><biblScope unit="volume">33</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="581">581</biblScope><biblScope unit="page" to="598">598</biblScope></imprint><idno type="ISSN">0741-0395</idno></series><idno type="istex">E937BC4066451E7BCC9EE3C30DE09667CA8652EE</idno><idno type="DOI">10.1002/gepi.20410</idno><idno type="ArticleID">GEPI20410</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0741-0395</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>epidemiology</term><term>genetics</term><term>gene‐disease associations</term><term>gene‐environment interaction</term><term>genome‐wide association</term><term>meta‐analysis</term><term>reporting recommendations</term><term>systematic review</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the STrengthening the Reporting of OBservational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modelling haplotype variation, Hardy‐Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis. Genet. Epidemiol. 33:581–598, 2009. © 2009 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Grèce</li><li>Géorgie (pays)</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Californie</li><li>Canton de Berne</li><li>District de Fribourg-en-Brisgau</li><li>Massachusetts</li><li>Minnesota</li><li>Ontario</li><li>Québec</li><li>Texas</li><li>État de New York</li></region><settlement><li>Berne</li><li>Fribourg-en-Brisgau</li><li>Montréal</li><li>Toronto</li></settlement><orgName><li>Université McGill</li><li>Université de Berne</li><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Little, Julian" sort="Little, Julian" uniqKey="Little J" first="Julian" last="Little">Julian Little</name></noRegion><name sortKey="Birkett, Nick" sort="Birkett, Nick" uniqKey="Birkett N" first="Nick" last="Birkett">Nick Birkett</name><name sortKey="Fortier, Isabel" sort="Fortier, Isabel" uniqKey="Fortier I" first="Isabel" last="Fortier">Isabel Fortier</name><name sortKey="Gagnon, France" sort="Gagnon, France" uniqKey="Gagnon F" first="France" last="Gagnon">France Gagnon</name><name sortKey="Grimshaw, Jeremy" sort="Grimshaw, Jeremy" uniqKey="Grimshaw J" first="Jeremy" last="Grimshaw">Jeremy Grimshaw</name><name sortKey="Hutchings, Kim" sort="Hutchings, Kim" uniqKey="Hutchings K" first="Kim" last="Hutchings">Kim Hutchings</name><name sortKey="Infante Ivard, Claire" sort="Infante Ivard, Claire" uniqKey="Infante Ivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name><name sortKey="Johnson, Candice Y" sort="Johnson, Candice Y" uniqKey="Johnson C" first="Candice Y." last="Johnson">Candice Y. Johnson</name><name sortKey="Little, Julian" sort="Little, Julian" uniqKey="Little J" first="Julian" last="Little">Julian Little</name><name sortKey="Mclaughlin, John" sort="Mclaughlin, John" uniqKey="Mclaughlin J" first="John" last="Mclaughlin">John Mclaughlin</name><name sortKey="Mclaughlin, John" sort="Mclaughlin, John" uniqKey="Mclaughlin J" first="John" last="Mclaughlin">John Mclaughlin</name><name sortKey="Moher, David" sort="Moher, David" uniqKey="Moher D" first="David" last="Moher">David Moher</name><name sortKey="Paterson, Andrew" sort="Paterson, Andrew" uniqKey="Paterson A" first="Andrew" last="Paterson">Andrew Paterson</name><name sortKey="Stewart, Alex" sort="Stewart, Alex" uniqKey="Stewart A" first="Alex" last="Stewart">Alex Stewart</name><name sortKey="Tait, Valerie" sort="Tait, Valerie" uniqKey="Tait V" first="Valerie" last="Tait">Valerie Tait</name><name sortKey="Wells, George" sort="Wells, George" uniqKey="Wells G" first="George" last="Wells">George Wells</name><name sortKey="Wiens, Miriam" sort="Wiens, Miriam" uniqKey="Wiens M" first="Miriam" last="Wiens">Miriam Wiens</name><name sortKey="Zou, Guang Yong" sort="Zou, Guang Yong" uniqKey="Zou G" first="Guang Yong" last="Zou">Guang Yong Zou</name><name sortKey="Zou, Guang Yong" sort="Zou, Guang Yong" uniqKey="Zou G" first="Guang Yong" last="Zou">Guang Yong Zou</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Higgins, Julian P T" sort="Higgins, Julian P T" uniqKey="Higgins J" first="Julian P. T." last="Higgins">Julian P. T. Higgins</name></noRegion><name sortKey="Davey Mith, George" sort="Davey Mith, George" uniqKey="Davey Mith G" first="George" last="Davey-Smith">George Davey-Smith</name><name sortKey="Golding, Jean" sort="Golding, Jean" uniqKey="Golding J" first="Jean" last="Golding">Jean Golding</name></country><country name="Grèce"><noRegion><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name></noRegion></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name></region><name sortKey="Cohen, Barbara" sort="Cohen, Barbara" uniqKey="Cohen B" first="Barbara" last="Cohen">Barbara Cohen</name><name sortKey="Freedman, Matthew" sort="Freedman, Matthew" uniqKey="Freedman M" first="Matthew" last="Freedman">Matthew Freedman</name><name sortKey="King, Richard" sort="King, Richard" uniqKey="King R" first="Richard" last="King">Richard King</name><name sortKey="Scheet, Paul" sort="Scheet, Paul" uniqKey="Scheet P" first="Paul" last="Scheet">Paul Scheet</name><name sortKey="Williamson, Robin E" sort="Williamson, Robin E" uniqKey="Williamson R" first="Robin E." last="Williamson">Robin E. Williamson</name><name sortKey="Zecevic, Maja" sort="Zecevic, Maja" uniqKey="Zecevic M" first="Maja" last="Zecevic">Maja Zecevic</name></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Von Elm, Erik" sort="Von Elm, Erik" uniqKey="Von Elm E" first="Erik" last="Von Elm">Erik Von Elm</name></region></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Von Elm, Erik" sort="Von Elm, Erik" uniqKey="Von Elm E" first="Erik" last="Von Elm">Erik Von Elm</name></region></country><country name="Géorgie (pays)"><noRegion><name sortKey="Khoury, Muin J" sort="Khoury, Muin J" uniqKey="Khoury M" first="Muin J." last="Khoury">Muin J. Khoury</name></noRegion><name sortKey="Gwinn, Marta" sort="Gwinn, Marta" uniqKey="Gwinn M" first="Marta" last="Gwinn">Marta Gwinn</name></country><country name="Pays-Bas"><noRegion><name sortKey="Van Duijn, Cornelia" sort="Van Duijn, Cornelia" uniqKey="Van Duijn C" first="Cornelia" last="Van Duijn">Cornelia Van Duijn</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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